Tissue Engineering in Wound Repair
Tissue engineering developed the therapeutic potential for wound healing and for wounds
that are not open to primary closure. Over the past years, there have been remarkable
advances in our understanding of the molecular and cellular processes involved
in acute wound healing
and in the pathobiology of chronic wounds. Improved knowledge has led to
wound care advances. There are there important areas of research involved in stimulating
complex wounds to heal by using biologics (growth factors and stem cells), use
of artificial extracellular matrices for regeneration, effect of mechanical
forces on wound healing. Four components are essential for tissue engineering. Stem cells, a
matrix or scaffold, a bioreactor (culture medium), cytokines. The two major
approaches have been utilized to develop engineered tissue includes In vitro
(cellular constructs) and In vivo (acellular constructs). The goal of
tissue engineering has been initially to substitute in patients with extensive
burns wounds with tissue engineered autologous materials.
- Tissue engineered skin
- Tissue engineering in wound healing
- Skin substitutes
- Scaffolds for tissue repair and healing
- Extracellular Matrix and Scaffold
- Tissue engineered wound healing products