Scientific Program

Day 1

KEYNOTE SPEAKERS
  • Basics of advanced ultrasound wound and skin care: Technologies, devices, science and clinical outcomess

    Arobella Medical, LLC
    USA
    Biography

    Eliaz P. Babaev, Ph.D., Co-Founded Arobella Medical, LLC in 2006 and serves as its Chief Executive Officer and President. Dr. Babaev Co-founded Celleration Inc. and served as its Chief Technical Officer until July 2009 and Chief Executive Officer. Dr. Babaev worked as an ultrasound system design engineer and research scientist for DiaSorin, Inc., SpectRx, and AeroPag-USA, Inc. He served as the Head of Biomedical Engineering Laboratory and a Professor for State Technical University, Baku, USSR for 25 years. Dr. Babaev then immigrated to the U.S. in 1994 and worked as a senior technical consultant for several medical device companies. He served as Assistant Professor in the Biomedical Engineering Department of Bauman Moscow State Technical University. He has also been a Research Fellow in Biomechanics and Bioengineering at the Warsaw University of Technology and Bulgarian Academy of Sciences. Dr. Babaev graduated from Moscow-Bauman Technical University with a Ph.D. in Biomedical Engineering and Biomechanical Engineering in 1975. Dr. Babaev holds D.Sc. (Doctor of Science), Biomedical Engineering (Medical Ultrasound) in 1993 and D.Sc., Biomedical Instrumentations and Biomechanics from Latvian Academy of Science, Center For Biomechanics & Biomedical Engineering Riga, Latvia in 1991. He received B.S. and M.S. Degree in Mechanical Engineering (Industrial Ultrasound - NDT for Oil Reservoirs) in Azerbaijan Technical University Baku, Azerbaijan in 1969. Dr. Babaev has more than 40+ years expertise in Non-Imaging Medical Ultrasound and particularly in Ultrasound Wound Management, live tissue repair and in all the areas of advances in skin, wound care, nursing, tissue science, drug delivery systems, wound treatment technologies, tissue engineering, and body architectonics research and cancer research including apoptosis. 50+ US and 100+ Worldwide Patents are issued, numerous are pending, 50+ scientific articles, abstracts are published.

    Abstract

    Purpose Last 20 years Ultrasound wound and skin treatment has been shown grate interest in hospitals, clinics; wound care centers and doctors’ offices. The purpose of this presentation is to share of my about 50 years scientific/academic, industry and clinical experience on research (in vivo and in vitro, laboratory, bench, etc.), review, and evaluate the safety, validity and efficacy of ultrasound treatment of all types of acute and chronic wounds including diabetic foot ulcers and share the results with the existing and future users by enhancing their understanding of potential positive outcomes from using the different Ultrasound devices in wound management. Methods For wound treatment purposes, the low and high frequency ultrasound devices have been used, which are been marketed worldwide. The ultrasonic parameters and design of instruments are very influential and critical for different aspects of wound treatment, such as ultrasonic energy delivery to target, tissue fractionation/ fragmentation/ debridement, liquefaction/ histotripsy, erosion, homogenization, liquation and wound therapy. Ultrasound treatment applies effective ways to prevent damage to surrounding healthy tissue and to succeed in therapeutic wound treatment. Treatment was both contact and non-contact modes, depending on the manufacturers, devices and wound conditions such as acute, infected, chronic, trauma, burn, gun shut, hard-to-heal, etc. Results All wounds have reacted well to ultrasound treatment; some of the wounds have exceeded expectations compared to standard-of-care treatment vectors. Even painful wounds have been aggressively debrided with some devices without local anesthetics and without patient complaints. Granulation process had started within two (2) days. Discussion/Conclusion Ultrasound wound treatment device and method recommended for use in treatment of all types of wounds; depending on size, depth, infection, and other conditions, treatment time will vary. It kills the bacteria cells, increases blood flow in wound bed and periwound. Efficacy of the results correlates to numerous aspects of wave delivery and distribution of ultrasound energy to wound bed via multiple avenues of energy level, parameters, wave delivery concepts, e.g. contact and non-contact macro and micro-streaming.

  • Repurposing ingenol mebutate as a novel pharmaceutical therapy for normal and pathological dermal fibrosis

    Cardiff University
    United Kingdom
    Biography

    Ryan Moseley graduated from Swansea University with a BSc (Honours) Degree in Biochemistry in 1991. Later, he obtained his PhD from the School of Dentistry, University of Wales College of Medicine in 1996, examining the role of oxidative stress in periodontal disease. In 2008, Dr Moseley was appointed Lecturer in Tissue Repair Director of the CITER MSc Programme in Tissue Engineering at Cardiff University, being promoted to Senior Lecturer in 2012 and to Reader in 2017. Dr Moseley’s research focus on the mechanisms underlying cellular wound healing responses in dermal (normal skin, chronic wound, keloid and hypertrophic scar) and oral (oral mucosa, bone, dental pulp) tissues during health and disease. By understanding these mechanisms, his Research Group aims to develop stem cell-, biomaterial- and pharmaceutical-based strategies to address impaired healing in these tissues. Funding bodies worldwide have supported Dr Moseley’s research (>£2M awarded to date), including the MRC, NHMRC and Wellcome Trust, culminating in numerous published papers, filed patents with industrial partners in the dermal wound-healing sector (Convatec, Systagenix Wound Management, Peplin/LEO Pharma, QBiotics); and many conference prizes and awards.

    Abstract

    Excessive dermal scarring/fibrosis poses major challenges to Healthcare Services worldwide. This is confounded by existing therapies being unsatisfactory at preventing or arresting fibrosis. Therefore, there is significant need for novel anti-fibrotic therapies with improved efficacy. The anti-cancer drug, ingenol mebutate (IngM), is licensed for actinic keratosis and non-melanoma skin cancers. IngM also stimulates exceptional healing and reduced scarring in treated skin, implying IngM possesses potent anti-fibrotic properties. As transforming growth factor-?1 (TGF-?1)-driven, dermal fibroblast-myofibroblast differentiation is pivotal to scarring outcomes, fibroblasts and myofibroblasts represent viable IngM targets. This work evaluated IngM efficacy against normal (dermal) and pathological (keloid) fibroblasts/myofibroblasts; and its mechanisms of action. Human dermal and keloid fibroblasts were treated with IngM (0-10µg/mL) and rhTGF-?1 (10ng/mL); and assessed for myofibroblast differentiation by immunocytochemistry/QRT-PCR for ?-smooth muscle actin (?-SMA) expression/stress fibre formation; QRT-PCR/Western blotting of other myofibroblast-/extracellular matrix (ECM)-related genes/proteins; hyaluronan synthesis/assembly (ELISA, hyaluronan synthase QRT-PCR, pericellular localization); and Microarrays/protein validation analysis. Although IngM does not inhibit dermal fibroblast-myofibroblast differentiation, IngM alters myofibroblast pro-fibrotic ECM deposition due to enhanced degradation of type I collagen by up-regulated matrix metalloproteinases (MMP-1, MMP-9). IngM also increases myofibroblast hyaluronan synthesis by hyaluronan synthase-2. Although reduced MMPs and hyaluronan are hallmarks of keloid scars, increased MMP/hyaluronan levels were also identified in IngM-treated keloid fibroblasts; in addition to reversed keloid fibroblast-myofibroblast formation and reduced type I collagen expression. Therefore, IngM modulates dermal/keloid fibroblast differentiation and behaviour, inducing scar tissue resolution. Such findings support IngM development/repurposing as a novel anti-fibrotic therapeutic against normal and pathological dermal scarring.

  • TRPV4-TAZ signaling in matrix stiffness and TGF?1-induced epithelial-mesenchymal transition

    University of Maryland
    USA
    Biography

    Shaik O. Rahaman, PhD, is an Assistant Professor at the University of Maryland, USA. His laboratory is interested in elucidating the signaling events underlying the pathogenesis of atherosclerosis and fibrosis. Dr. Rahaman earned his PhD in Molecular Biology at Jadavpur University, and a BS in Human Physiology (Honors), and an MS in Biophysics and Molecular Biology from University of Calcutta. From 2000-2014, Dr. Rahaman worked at Cleveland Clinic, Cleveland, USA, as a Postdoctoral Fellow, eventually as a Project Scientist and Assistant Professor. He was the recipient of the American Heart Association Scientist Development Grant, NIH-R01 grant, and NSF grant. Dr. Rahaman is the author or co-author of 23 research papers in high impact international peer-reviewed journals of repute. Dr. Rahaman has given numerous invited talks nationally and internationally, and is a reviewer/editorial board member in numerous scientific journals. Dr. Rahaman also served as a reviewer for National Institute of Health (USA).

    Abstract

    Epithelial-mesenchymal transition (EMT) is an essential event in development, fibrogenesis, and oncogenesis. Emerging data support a role for both a mechanical signal, and a biochemical signal, in EMT. Here, we report evidence that transient receptor potential vanilloid 4 (TRPV4), a channel sensitive to both matrix stiffness and transforming growth factor ?1 (TGF?1) stimuli, is a likely mediator of EMT. We found that antagonism of TRPV4 blocked both matrix stiffness- and TGF?1-induced EMT in normal human primary epidermal keratinocytes, as determined by changes in morphology and alterations in expression of EMT markers including E-cadherin, N-cadherin, and ?-smooth muscle actin (?- SMA). In a murine dermal fibrosis model, TRPV4 deletion resulted in decreased expression of the mesenchymal marker, ?-SMA, and increased expression of epithelial marker, E-cadherin. Furthermore, we found that: i) TRPV4 was essential for the nuclear translocation of TAZ in response to matrix stiffness and TGF?1; ii) Antagonism of TRPV4 inhibited both matrix stiffness-induced and TGF?1-induced expression of TAZ proteins; and iii) TRPV4 antagonism suppressed both matrix stiffness-induced and TGF?1-induced activation of Smad2/3, but not of AKT. Altogether, these data identify a novel role for TRPV4 in regulating EMT in response to both matrix stiffness and TGF?1.

Workshop
Chair
Co-Chair
Speaker
  • Qoustic wound therapy system, from Arobella Medical LLC
    Time: 11:30-12:20
    Speaker
    Eliaz P. Babaev
    Arobella Medical, LLC
    USA
    Biography

    Eliaz P. Babaev, Ph.D., Co-Founded Arobella Medical, LLC in 2006 and serves as its Chief Executive Officer and President. Dr. Babaev Co-founded Celleration Inc. and served as its Chief Technical Officer until July 2009 and Chief Executive Officer. Dr. Babaev worked as an ultrasound system design engineer and research scientist for DiaSorin, Inc., SpectRx, and AeroPag-USA, Inc. He served as the Head of Biomedical Engineering Laboratory and a Professor for State Technical University, Baku, USSR for 25 years. Dr. Babaev then immigrated to the U.S. in 1994 and worked as a senior technical consultant for several medical device companies. He served as Assistant Professor in the Biomedical Engineering Department of Bauman Moscow State Technical University. He has also been a Research Fellow in Biomechanics and Bioengineering at the Warsaw University of Technology and Bulgarian Academy of Sciences. Dr. Babaev graduated from Moscow-Bauman Technical University with a Ph.D. in Biomedical Engineering and Biomechanical Engineering in 1975. Dr. Babaev holds D.Sc. (Doctor of Science), Biomedical Engineering (Medical Ultrasound) in 1993 and D.Sc., Biomedical Instrumentations and Biomechanics from Latvian Academy of Science, Center For Biomechanics & Biomedical Engineering Riga, Latvia in 1991. He received B.S. and M.S. Degree in Mechanical Engineering (Industrial Ultrasound - NDT for Oil Reservoirs) in Azerbaijan Technical University Baku, Azerbaijan in 1969. Dr. Babaev has more than 40+ years expertise in Non-Imaging Medical Ultrasound and particularly in Ultrasound Wound Management, live tissue repair and in all the areas of advances in skin, wound care, nursing, tissue science, drug delivery systems, wound treatment technologies, tissue engineering, and body architectonics research and cancer research including apoptosis. 50+ US and 100+ Worldwide Patents are issued, numerous are pending, 50+ scientific articles, abstracts are published.

    Abstract

    Purpose: Lately Ultrasound wound treatment devices has been shown grate results in hospitals, clinics; wound care centers and doctors’ offices. Among these devices Qoustic Wound Therapy System from Arobella Medical, LLC. successfully being used in Medical practice. The purpose of this presentation is to demonstrate advantages of QWTS on models IN VITRO with safety and high efficacy in Wound Management. Methods: For wound treatment purposes, the patented low frequency QWTS as a ultrasound wound treatment device have been used in US and internationally. Intention of this workshop to show role and advantages of patented sharp cutting edge of device in precise and selective fragmentation and volume removal of unwanted tissues on piece of fresh meat and oranges. Contact and non contact wound treatment modalities with and whit out of acoustic cavitation will be demonstrated as well. Difference of qurretes and design, parameters of ultrasound waves in treatment process will be shown to attendees. Results: Contact and non-contact wound treatment modalities with and whit out of acoustic cavitation will be demonstrated as well. Difference of qurretes and design, parameters of ultrasound waves in treatment process will be shown to attendees. Discussion/Conclusion: Arobella Medical’s QWTS as a Ultrasound wound treatment device and method recommended for use in treatment of all types of wounds; depending on size, depth, infection, treatment time and other conditions will be discussed.

  • Tube-Evac device is the new standard of care for surgical drains
    Time: 12:20-13:10
    Speaker
    Vance Shaffer
    Tube-Evac
    USA
    Biography

    Vance Shaffer, an experienced President with a demonstrated history of working in the medical device industry. He is having strong business development professional skilled in Customer Service, Medical Devices, Entrepreneurship, Strategic Planning, and Business Development. He was the inventor of Tube-Evac. Quick, easy, and safe! Give your patients and their caregivers the peace of mind they deserve after surgery. Tube-Evac is an award winning device that makes stripping surgical drainage tubes fast and easy, allowing for better patient outcomes. He studied Computer Science and Mathematics at University of Cincinnati and worked at various companies in data base and various commercial enterprises. In last 20 years, he was working with Cray Research and IBM Research where he taught PhD’s, Post Docs, and Professors how to optimize computer programs to run on High Performance Computer systems with hundreds or thousands of computers. These codes were for molecular modeling, environmental modeling, stellar modeling, radioactive conversion to inert glass, optimization of materials management, keeping track of materials, and many other codes.

    Abstract

    Background: Tube-Evac is an award-winning device that makes stripping surgical drainage tubes fast and easy, allowing for better patient outcomes. The Tube-Evac device was invented when my wife Linda had surgery in January 2008 and came home with drains. We were both terrible at clearing the drains and we had conflicting ways we were told for clearing the drains. As a result of this really awful experience I set about to make something that would be beneficial to those following after us so they would not go through the same awful experience we did ever again. Methods and Outcomes: The first try was to weld some bolts on to a pair of water pump pliers, add some rollers and restrictor plates then bingo I had a working model. Quite crude but it worked. The next step was to reduce the size – a lot – and make it out of plastic. We met with Plastic Concepts in Jacksonville, Florida and they introduced us to a prototype builder. We worked with him until we had a device almost exactly the size it is today – a little over 1 inch width by 2 inches length with a set of rollers in it. The prototype had no hinges because it was layered 1/1000 inch at a time with very hard plastic so hinges were not possible. It was simply two halves that were laid one on each side of the drain and then rolled down the drain. It was crude but worked perfectly. The next step was to make a stainless steel die which we could use to do the plastic injection molding. This was very expensive and took over two months to make the die. However this one cavity die worked great and we could make Tube-Evac devices. A few years later we made a 4 cavity die. We now had the capacity to make 4,000,000 TubeEvac devices per year. Mayo Clinic tested 500 of the Tube-Evac devices in 2009 and loved them. They were our first customer and still are.

  • A workshop on PRP in wound Management - STARS technique
    Time: 14:10-15:00
    Speaker
    Chandrashekhar Mahakalkar
    Datta Meghe Institute of Medical Sciences
    India
    Biography

    Chandrashekhar Mahakalkar has completed his MS in 2006 from RTM, Nagpur University. He is the professor in General Surgery of Datta Meghe Institute of Medical Sciences (deemed to be University), India. Currently, working as Director, Center of Excellence, Technological Interventions in Medicine, DMIMS (DU), India and also Chief Medical Superintendent, AVBRH, DMIMS (DU), India. He has over 30 publications that have been cited over 150 times, and his publication H-index is 2 and has been serving as an reviewer for reputed Journals.

    Abstract

    This workshop is intended to introduce and orient the health care providers towards the management of Platelet rich Plasma in wound management by STARS Technique. The Author have developed a clinical protocol “Sandeep’s Technique for Assisted Regeneration of Skin (STARS)” at their centre. The technique is utilises the autologous Platelet rich plasma as a mono therapy for treatment of wounds including complex wounds such as diabetic ulcers , bed sores , acute ischaemic injuries , large wounds with necrosis , infections and exposed deeper tissues. The results have been a very promising ones as shown below: The workshop has 3 sub talks / demonstrations: A. Orientation towards PRP and its properties B.The preparation of PRP from Autologous Blood . C. The clinical application of the PRP for wound management including the safety and precautions. The workshops aims at training HCP’s for safe and effective use of PRP through STARS technique for wound management , and also help develop deeper insight into the clinical applications of cellular therapy for tissue bioengineering & regeneration and their incorporating into day to day Patient care. It is a very simple technique which can be performed by all health care providers including Nursing and primary care physicians.

Scientific Sessions: Wound and Wound Care | Wound Healing and Tissue Repair | Wound Care and Ulcers | Wound Care and Nursing | Burns and Advanced Wound Care | Advances in Skin & Wound Care | Skin and Wound Healing | Wound, Ostomy & Continence Nursing | Stem Cells & Tissue Regeneration | Wound Care Management & Therapies
Chair
Co-Chair

Day 2

KEYNOTE SPEAKERS
  • Bioptron hyperpolarized light (HPL): Advancement of bioptron vertical linearly polarized light (VLPL) in the treatment of skin & chronic wounds

    Association of Wound Management
    Bosnia and Herzegovina
    Biography

    Jasmina Begic is a Medical Consultant for BIOPTRON, Zepter Internastional for Bosnia and Herzegovina, Founder of Association for Wound management in B&H, Founder and author of Euro-Asian Forum, one of founder of www.BALWMA.org. She is currently working as a Dermatovenerologyst in Bioptron International team-Wound Healing and also a certified VCC trainer of elderly care; certified VCC trainer of manager EU founds; certified practitioner of TCM; certified practitioner of herbal medicine. She finished her graduation and post-graduation studies at Medical School of University Sarajevo, Sarajevo, Bosnia and Herzegovina and completed her PhD in the field of Tissue Regeneration and Wound Healing from Indian Institute of Technology, Kharagpur. She did volunteer works in Association for Wound management in Bosnia and Herzegovina (AWMinB&H) from 2008 till present. She is also active member in UEMS TF WH, EWMA, EADV. Her projects are involved in Clinical Research “Appliance Bioptron polarized light (480 -3400nm) in the therapy of dermatosis: Acne vulgaris and Ulcer cruris” which is approved by members of Scientifically Research Institute of Clinical Center of University in Sarajevo and Members of Ethics Commitee of Clinical Center University in Sarajevo; Euro-Asian Forum of Association for Wound Management (2011, 2012, 2014, 2016, 2018); Academy for health and social occupation (2013); Implementation of Traditional Chinese Medicine in health and stationary institution in Bosnia and Herzegovina and country of Western Balkan (2014); Balkan Wound Management Association (2015); Integrative Medicine in Postoperative Management (2017); Integrative medicine: Prevention is best cure of Pressure Ulcers (2017).

    Abstract

    Introduction: Light therapy is one of the oldest therapeutic methods used by humans historically. Many of ancient civilizations, the Greeks, the Egyptians and the Arabs, used the light and its healing effects in the treatment of diseases. The founder of modern light therapy, Danish physician Niels Ryberg Finsen, was awarded the Nobel Prize in Medicine (1903) for his research in light therapy and his exceptional therapeutic achievements. When diffused light passes through the Brewster optical Unit, light becomes vertical lineraly polarized light (VLPL) perfectly ordered with the waves that propagate in parallel planes in one direction, covers visible & part of the infrared wavelengths of light (wave length 480 – 3400 nm) degree of polarization 95%, power density 40mW/cm2, light energy 2,4J/cm2) and is known to induce a biological response, known as photobiostimulation A highly qualified team of internationally world-renowned experts and scientists has developed BIOPTRON Hyperpolarized light therapy systems . During experiments with graphite, a British-American team of researches from the Rice University ( U.S) obtained the miraculous fullerene C60 in 1985 in their labaratory. The scientists Kroto, Curl and Smalley were awarded the Nobel Prize in Chemistry ( 1996) for their discovery. A diffuse stream of photons passes through a Bioptron Brewster Optical Unit that orders them into a parallel plane stream, called Linearly Polarized Light (LPL). The ideally ordered structured hyperharmonized light which greatly positively influences our body: ideally interacts with the same structured body matter. HPL transfers information of the ideal harmon y of C60 and it’s energetic state into the organism - biological structures, inducing harmonization with them and bringing equilibrium in energetically disturbed biological structures; accelerating natural healing and self-regenerative processes. Chronic wounds of different etiology are important medical, economic and social problem and a major cause of morbidity in the population. The number of people with wounds and the demand for health services will continue to increase due to changing demographics and an expected rise in the number of people with chronic diseases. Chronic venous insufficiency leads to significant costs worldwide because of its high prevalence and increased risk of complication, e.g. 1-1,5% of the EU population has one or more chronic wounds costing 1-2% of the health care budget. The effects of Bioptron LPL on the wound healing involve two main pathways: 1) the fibroblastic structural pathway and; 2) immunological cytokine pathway. Aim: The aim of this clinical research was to evaluate the effects of Bioptron linearly polarized light (480-3400nm) in the therapy of dermatosis. Methods, Subjects: During the one year study we treated 50 patients with leg ulcers of different etiology. Bioptron linearly polarized light (LPL) covers visible & part of the infrared wavelengths of light (wave length 480 – 3400 nm, degree of polarization 95%, power density 40mW/cm2, light energy 2,4J/cm2) and is known to induce a biological response, known as photobiostimulation. The process of wound healing has 3 phases, which are not distinctly separated; 1st Inflammatory Phase (Catabolic Phase): hemostasis and inflammation, occurring immediately upon injury through 4-6 days. 2nd. Proliferative Phase (Anabolic Phase) is characterized by epithelization and angiogenesis (proliferation and migration). 3rd Re-modeling Phase is also known as phase of maturation and epithelization. All patients were treated with topic therapy according to TIME principles of Wound bed preparation (WBP). Each patient was treated with polarized light for 8 min/day, a distance of 10cm, like supplementary therapy. The effects of linearly polarized light (LPL) on the wound healing of leg ulcers of different etiology were evaluated on daily basis. Long–term follow-up was performed after 1 month, 3 months, 6 months and 1 year. Results: The results of this study showed that linearly polarized light (LPL) has a high influence on all phases of healing leg ulcers what resulted with faster healing of ulcers, completing the healing up process, less infection, eradications in soma case of MRSA, reduce infection, time of hospitalization and length of antibiotic therapy, reduction of pain sensation, and improvement of quality of life.

  • Reconstruction to regeneration: Beginning of a new era in the wound management

    Datta Meghe Institute of Medical Sciences
    India
    Biography

    Sandeep Shrivastava is Professor of Orthopaedics. He is also the Director at Centre for Autologus Platelet Rich Plasma Biotechnological Interventions; C.E.O.(Hospitals ) and Ex Dean of the Medical School at Datta Meghe Institute of Medical Sciences , a Health University, at India situated in rural backdrop of city Wardha. He is Chairman of Limb Deformity Correction and Reconstruction Clinic at Dept. of Orthopaedics. He did his graduation and post-graduation from G R Medical College, Gwalior, India. He have published more than 60 International papers; presented 75 International papers at different global forums, 2 books and hold 5 copyrights /patents on ranging interests from Medical Education to Bio- Informatics. As Clinical biotechnologist & Reseracher, he has developed the therapy “Sandeep’s Technique for Assisted Regeneration of Skin (STARS)” for wound healing, which is an attempt to find an ideal solution for millions who continue to suffer from complex wounds. He has travelled extensively to over 25 countries, delivering various talks & have also been conducting life skill Workshop - “Escape to Lifescape”.

    Abstract

    Background & Introduction: The management of wounds has been a huge challenge for all health care providers, particularly those which are complex in nature and associated with exposed bones, tendons, implants, infections etc. The primary occurrence of open injuries in fractures tend to modify the management protocols and delays the union strategies. Association of infection is catastrophic, and no surgeon wants it to happen. Similarly, the necrosis of surgical flaps leading to exposure of implants and underlying bones is a worse scenario, specially after a well-intended and performed surgeries. This work is dedicated to evolve a solution which can lead to predictable wound healing in all such cases with minimum of surgical intervention; drugs such antibiotics and analgesics; and simplified local care. The author have developed a technique , which is based on management of wounds with Platelet Rich Plasma and intend to share and present his work on the same in this Oration. Material & Methodology: At the Dept. of Orthopaedics, J.N.Medical College ,Wardha working at Rural tertiary care centre , the Project PRP_ Biotechnological Intervention was started in 2012 and after 5 years of different observations of usage of PRP in wounds , we developed a technique now called as “STARS Technique” - “Sandeep’s technique for Assisted Regeneration of Skin”. This involves use of autologous PRP as the Mono-therapy and mainstay treatment for almost all wounds including the above described complex wounds. Its basically infiltration of PRP followed by Moist Saline dressings. A pilot case based prospective interventional study involving 170 Patients is now completed. Observations & Results: The data generated is recorded in the form of Photographs of each Patients till the wound have healed completely or near completion of treatment. It is analysed towards wound healing, control of infection and final outcomes. Further this data is matched with Laboratory data generated towards culture from wounds, Patient Platelet & Haemogram profiles etc, so that safety of technique is studied. Based on the observations of wound healing - Stages and Pattern of assisted healing has also been identified and studied. The results are excellent with complete control of infections, a predictable healing in almost all cases including bed sores, diabetic sores, complex wounds involving bones, tendons and near necrotic flaps and tissues. The results in the last group of near necrosis / gangrenous situation is a quantum jump in the history of mankind, where in reversal/ restriction of damage has been achieved perhaps for the first time, restricting the morbidity to the minimum. We have been able to salvage limbs which were referred for amputations. Result & Conclusion: The emergence of a new modalities based on Regenerative Medicine is predicted to change the managements of health problems. Inclusions of Stem cells, Mesenchymal Stem cells or Platelet in treatment protocol for complex problems will probably give current outcomes a flip. The regeneration as a tool for healing is going to be very powerful options, and have all potentials to be the mainstay treatment, moving ahead from concept of Drugs, Devices and Dressings. The main restriction for their clinical applications is accessibility; cost and still some ethical issues, particularly for Stem cells. Platelet as a regenerative product, easily overcome all these reservations. But few things about PRP usage are still unclear in current literature. This study and its results, takes a leading stride in forwarding this march of Regenerative Medicine into the clinical practices and building solution for problems which were referred to as difficult to solve or incurable. Through this study we again reemphasise, that its important to build clinical solutions focussed on breakthrough researches happening in the laboratory, and develop them in a mode and manner, where they can remain relevant to all stake holders including Medical doctors; other health care providers and Patients; particularly in terms of Applicability, Replicability/Reproducibility and Affordability.

  • Minimal invasive surgery in infected diabetic foot ulcer, a case study

    Malaysian Diabetic Limb Salvaging Society
    Malaysia
    Biography

    Mogan Naidu Graduated from AIMST University Malaysia with MBBS back in 2008. He then pursued his interest in Wound Healing and Tissue Repair in CMC Vellore South India, Orthopedics Department Hospital Taiping Malaysia, and mostly in his own founded Center MediAsia™ Advance Wound Dressing & Tissue Repair Center. MediAsia™ was established back in year 2012 as pioneer in Private Wound Care Services in Malaysia with 2 doctors specializing in Tissue repair and Diabetic Foot management. Currently MediAsia™ has 15 Doctors and associates with all leading Specialties and hospitals related to Wound healing in Diabetic. Dr. Mogan Founded MediAsia™ Orthotic and Prosthetic Center in 2013 which also engaged in researching and developing Affordable and reliable Foot Devices and Insoles to heal and Prevent Foot ulcers. He also established MediAsia™ Maggot (Larvae) Biotherapy Center and Diabetic Care Center in 2014 which is one of its kind in Malaysia. He is an active international Speaker for Practice in Advance Diabetic Wound Management& Tissue Repair, Diabetic Limb Salvage and Minimal Invasive Surgeries (MIS) in Diabetic Foot Infection. He was appointed as the International Faculty Member of Prestigious Vascular Society of India (VSI) in the year 2017. He is also the Founder and established The Malaysian Diabetic Limb Salvaging Society (MDLSS) since 2016. Dr. Mogan has organized various Prestigious CME’s, Hands on Workshops, Conferences and Summits on Wound healing and Tissue repair in Malaysia and Overseas. The Free Diabetic Foot Screening Program (FDFSP) lead by Dr. Mogan is the only program in Malaysia and South east Asia fully engaged in Preventive awareness and Pre-Ulcerative screening under MDLSS. He and his team has successfully treated over 3000 DFU/DFI cases which would be otherwise subjected for Lower Limb Amputations.

    Abstract

    Minimal invasive surgery (MIS) procedures are increasing in popularity because of its known reduced complications and faster recovery. The objective of this case study was to determine the outcome of infected diabetic foot ulcer (DFI) with MIS technique. A 65years old women with multiple comorbid presented with left great toe ulcer, Wagner stage 4 for three weeks. Examination revealed there was a necrotic patch at left great toe and lateral mid plantar subcutaneous infection with foul smelling pus noted. Advance neuropathy with feeble distal pulses were palpable. Blood investigation revealed high white blood cell and pus culture showed pseudomonas pathogen. X-ray of the left foot showed resorption at distal phalanx. Minimal opening via mid plantar of left foot was done for sinus tract exploration removal of flexor hallucis Longus tendon. Patient was initially on intravenous antibiotics and the subsequently switched to oral for four weeks. Additionally, patient was advised for total offloading of left foot for a month. Serial tissue repair was done within the subcutaneous level until the wound closed assisted by MediAsia Home Offloading device. Subsequently she made full recovery within 2 months of follow up and discharged. This case demonstrates a classical presentation of infected diabetic foot ulcer which resolved quickly with minimal invasive surgery and supportive therapy.

Workshop
Chair
Co-Chair
Speaker
  • Negatively charged microspheres: Wound conditions tailored therapy
    Speaker
    Vladimir Ritter
    Polyheal Ltd
    Israel
    Biography

    Vladimir Ritter has completed his PhD at the age of 31 years from Institute of Biophysics of the Academy of Sciences of USSR, Puschino-Oka. Dr.Ritter serves as CEO and CTO of company Polyheal, Israel, that he established in 1996. Inventor of microspheres based technology for wound healing and tissue regenerationn. Author of number of patents and manuscriots.

    Abstract

    New technology as a result of interdisciplinary approuch. Biophysical research of polymers effect of phosphlolipid membranes fusion led to development of a new class of wound healing products. Negatively charged microspheres (NCM) are made from polystyrene are non-biodegradable 5 micron in diameter particles, do not carry any active ingredient and are used as a water suspension. Cells are actively attached and spread on the surface of microspheres, the microspheres are not engulfed by cells of any kind tested, and the cell–microspheres interaction is limited by extracellular membrane. Cells attachment to microspheres triggers in vitro modulation of the balance of cytokines by monocytes, lymphocytes and fibroblasts, stimulates free radicals production by inflammatory cells, collagen production by fibroblasts, proliferation and cell migration of fibroblasts, keratinocytes, endothelial cells, facilitation the Ca2+ influx to fibroblasts and lymphocytes. Cell response depends on amount and properties of microspheres and the metabolic conditions of cells. In animal models wound healing (excsisional full thickness wounds, burns) microspheres causes accelerated wound closure accompanied with influx of macrophages, elevation of collagen. In double blind controlled clinical study significant acceleration of wound healing in chronic stagnant wounds with exposed tissues and coverage of at least 75% of wound area with healthy granulation tissue within 4 weeks has been observed. Conclusion: Non biodegradable polystyrene charged microspheres influence activity and proliferation of various types of cells presented normally in wounds that might explain the efficacy and diversity of etiologies and conditions of a successfully treated wounds by NCM based commercial products.

  • Tissue repair and regenerative medicine
    Speaker
    Somy Sabbaghan
    Revita Lifesciences
    India
    Biography

    Somy S, D Phil student in regenerative medicine (New Delhi India), as Supervisor Medical Pathology. She had done research in regenerative medicine from Biotechnology department at University Bangalure and Intership from Columbia Asia Hospital in Medical Pathology. Her clinical activities include Stem cells Medical Application (mesenchymal stem cells from Bone Marrow); Stem Cells Medical purification and Application (Human Placenta) and PRP Preparation and Application (face, knee, neck, hands, chest).

    Abstract

    Preliminary discoveries of the efficacy of cell therapy are currently being translated to clinical trials. There continues to be extraordinary anticipation that stem cells will advance the current therapeutic regimen for orthopaedic and neurological diseases as well. Clinical situations like AVN, Non unions, osteoarthritis have seen increased application of stem cells. Mesenchymal Stem cells restore blood supply through therapeutic angiogenesis and supply of progenitor and other multipotent stem cells along with growth factors where new tissue is required. Bone marrow-derived stem cells (BMSCs) and adipose tissue derived (ADSCS) are a promising strategy. Promote structural and functional repair by changes in the brain microenvironment, with regard to effects on endogenous neurogenesis, rejuvenation of dormant neurons and remyelination. We present the current status of using adult stem cells to treat in Non-unions. osteoarthritis of knee, Traumatic brain and Spinal cord injury, ALS, autism and cerebral palsy for which current therapies are limited., including the basic cell types and potential mechanisms of action, and the initiation of clinical trials.

Scientific Sessions: Wound Care and Ulcers | Wound Care and Treatment | Wound Healing and Regenerative Medicine | Wound and Pain Management| Wound Care and Diabetes| Wound Care and Infection Control | Wound, Ostomy & Continence Nursing | Wound Care & Dressing | Wound Care Products | Wound Care & Lymphedema
Chair
Co-Chair

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Terms and Conditions

Responsibility

Delegates are personally responsible for their belongings at the venue. The Organizers will not be held responsible for any stolen or missing items belonging to Delegates, Speakers or Attendees; due to any reason whatsoever.

Insurance

Registration fees do not include insurance of any kind.

Transportation

Please note that any (or) all transportation and parking is the responsibility of the registrant.

Press/Media

Press permission must be obtained from allied academies Conferences Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The allied academies is an objective third-party nonprofit organization. This conference is not associated with any commercial meeting company.

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference. Once your registration is complete, please contact to request a personalized letter of invitation.

Regarding refunds, all bank charges will be for the registrants account.


Cancellation, Postponement, and Transfer of Registration

Cancellation Policy

If an allied academy cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another allied academies event which must occur within one year from the date of cancellation.

Postponement

If allied academies postpone an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another e allied academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization if registered person is unable to attend the event. Transfers must be made by the registered person in writing towoundcare@alliedmeetings.com. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies. if the person is unable to attend one of the conferences.

However, Registration cannot be transferred if it is intimated within 14 days of the respective conference.

The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied academies, including the inability to obtain a visa.

Refund Policy

If the registrant is unable to attend and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-

Before 60 days of the conference: Eligible for Full Refund less $100 Service Fee

Within 60-30 days of Conference: Eligible for 50% of payment Refund

Within 30 days of Conference: Not eligible for Refund

E-Poster Payments will not be refunded.

Accommodation Cancellation Policy

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied academies will advise the cancellation policy of your accommodation provider, prior to canceling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

Authorization Policy


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